Year: 2017
Type: article
Abstract: Vaccination is the most effective strategy for prevention of infectious diseases. The health of the human race has been enormously benefited from vaccination, and various vaccines have effectively saved a lot of lives from morbidity and mortality to date. However, development of new vaccines is increasingly facing challenges to meet growing threat from not only existing infectious diseases but also emerging / re-emerging infectious diseases due to global expansion of tourism and human migration. Generally, modern vaccines are safer, but they tend to be highly targeted and less immunogenic on their own. As a result, they often require an immunogenic adjuvant to enhance immune responses and achieve clinical significance. However, many licensed and candidate chemical or biological adjuvant have been linked to side effects, posing safety concern. A new approach, namely laser-based physical adjuvant, may represent alternative strategy to conventional vaccine adjuvant. Historically, Russian military scientists have put an effort to developing vaccine adjuvant using laser light from 1970’s. Subsequently, US scientists including us reproduced their results and further expanded investigation of use of laser to augment the immune response.
Source: Nippon Laser Igakkaishi
Authors: Yoshifumi Kimizuka, Satoshi Kashiwagi
Institutions: Harvard University, Massachusetts General Hospital
Language: German
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2764195480