Work

Thrombotic Microangiopathy and the Kidney

Year: 2017

Type: review

Abstract: Thrombotic microangiopathy can manifest in a diverse range of diseases and is characterized by thrombocytopenia, microangiopathic hemolytic anemia, and organ injury, including AKI. It can be associated with significant morbidity and mortality, but a systematic approach to investigation and prompt initiation of supportive management and, in some cases, effective specific treatment can result in good outcomes. This review considers the classification, pathology, epidemiology, characteristics, and pathogenesis of the thrombotic microangiopathies, and outlines a pragmatic approach to diagnosis and management.

Source: Clinical Journal of the American Society of Nephrology

DOI: 10.2215/cjn.00620117

Authors: Vicky Brocklebank, Katrina M. Wood, David Kavanagh

Institutions: National Health Service, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle University, Newcastle upon Tyne Hospital

Language: English

Topic: Complement system in diseases

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Kidney Research UK, Medical Research Council