There's no place like home - HGF-c-MET signaling and melanocyte migration into the mammalian cochlea
Year: 2017
Type: editorial
Abstract: During vertebrate embryonic development, neural crest cells arise from the border region between neural and non-neural ectoderm, migrate to various locations of the embryonic body and differentiate into diverse tissues. In the cochlea of the inner ear, the neural crest cell-derived melanocyte is an important component to form the stria vascularis, a non-sensory structure crucial for auditory function. Our recent conditional knockout study in the mouse indicates that in the absence of HGF-c-MET signaling, neural crest cells properly migrate and find the right region of the prospective stria vascularis in the cochlear epithelium, but fail to start incorporating into the epithelium. Our study has shed light on a homing issue of migrating cells that is evident during development, or in cancer cell metastasis.
Source: Neurogenesis
Author: Takahiro Ohyama
Institution: University of Southern California
Language: English
Subfield: Sensory Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W2765166149