Milk Intake at Midlife and Cognitive Decline over 20 Years. The Atherosclerosis Risk in Communities (ARIC) Study
Year: 2017
Type: article
Study design: Observational Study
Abstract: Background: Faster rates of cognitive decline are likely to result in earlier onset of cognitive impairment and dementia. d-galactose, a derivative of lactose, is used in animal studies to induce neurodegeneration. Milk is the primary source of lactose in the human diet, and its effects on cognitive decline have not been fully evaluated. Objective: Assess the association of milk intake with change in cognitive function over 20 years. Methods: A total of 13,751 participants of the Atherosclerosis Risk in Communities (ARIC) cohort completed a food frequency questionnaire and three neurocognitive evaluations from 1990 through 2013. Two single nucleotide polymorphisms (SNPs) were used to determine lactase persistence (LCT-13910 C/T for Whites and LCT-14010 G/C for Blacks). Mixed-effects models were used to study the association of milk intake with cognitive change. Multiple imputations by chained equations were used to account for attrition. Results: Milk intake greater than 1 glass/day was associated with greater decline in the global z-score over a 20-year period. The difference in decline was 0.10 (95% CI: 0.16, 0.03) z-scores, or an additional 10% decline, relative to the group reporting “almost never” consuming milk. Conclusions: Replication of these results is warranted in diverse populations with greater milk intake and higher variability of lactase persistence genotype.
Source: Nutrients
DOI: 10.3390/nu9101134
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,499
Awards: G1052397333, G1135917780, G1243299691, G1304838974, G1328425623, G1527150935, G1691174148, G173303992, G1941623656, G2195207551, G2290673161, G278284130, G2818629771, G3114902838, G3410686264, G3462919067, G4290615481, G457330776, ARIC Neurocognitive Study (ARIC-NCS) Renewal UNC 4 of 5, G5053595415, G5364873420, G54465602, G567847597, G583528397, G6548750934, G667954196, ARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5, G6805325053, ARIC Neurocognitive Study (ARIC-NCS), G6978868085, Cardiovascular Epidemiology Training Grant, Nutrition Obesity Research Center (NORC)
OpenAlex ID: W2765214374