Work

Effects of type 2 inflammation on epithelial Wnt signaling and TGM2 mediated leukotriene production

Year: 2017

Type: dissertation

Abstract: In asthma, leukotrienes (LTs) are important inflammatory mediators and Wnt signaling is highly implicated in lung fibrosis. Recent data suggest the contribution of epithelial cells to LT production by TGM2 and remodeling by altered epithelial Wnt signaling. In this study the role of epithelial Wnt signaling and TGM2 in asthma was investigated. Epithelial Wnt5a enhanced TGM2 expression in macrophages. TGM2 further induced LT production by activating sPLA2-X. Therefore a novel epithelial derived LT regulating remodeling cascade of Wnt5a, TGM2 and sPLA2-X was identified.

Source: mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich)

Author: Katharina Dietz

Language: English

Topic: Asthma and respiratory diseases

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2765248646

Cites: 204

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Related to: 10