Work

Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms

Year: 2017

Type: article

Abstract: Early-life stress, including maternal separation (MS), increases the vulnerability to develop mood disorders later in life, but the underlying mechanisms remain elusive. We report that MS promotes depressive-like symptoms in mice at a mature stage of life. Along with this behavioral phenotype, MS drives reduction of GABA B -GIRK signaling and the subsequent lateral habenula (LHb) hyperexcitability—an anatomical substrate devoted to aversive encoding. Attenuating LHb hyperactivity using chemogenetic tools and deep-brain stimulation ameliorates MS depressive-like symptoms. This provides insights on mechanisms and strategies to alleviate stress-dependent affective behaviors.

Source: Nature Communications

DOI: 10.1038/s41467-017-01192-1

Authors: Anna Tchenio, Salvatore Lecca, Kristina Valentinova, Manuel Mameli

Institutions: Inserm, Institut du Fer à Moulin, Université Pierre-et-Marie-Curie, University of Lausanne

Language: English

Topic: Neurotransmitter Receptor Influence on Behavior

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $6,990