Work

The Utility of68Ga-DOTATATE Positron-Emission Tomography/Computed Tomography in the Diagnosis, Management, Follow-Up and Prognosis of Neuroendocrine Tumors

Year: 2017

Type: review

Abstract: Neuroendocrine tumors (NETs) are rare neoplasms that emerge mainly from the GI tract, pancreas and respiratory tract. The incidence of NETs has increased more than sixfold in the last decades. NETs typically express somatostatin receptors on their cell surface, which can be targeted by 'cold' somatostatin analogs for therapy or by 'hot' radiolabeled somatostatin analogs for tumor localization and treatment. 68-Gallium-DOTA peptides (DOTATATE, DOTATOC, DOTANOC) positron emission tomography/computed tomography is a highly accurate imaging modality for NETs that has been found to be more sensitive for NET detection than other imaging modalities. In the current review, we will discuss the clinical utility of 68-Gallium-DOTATATE positron emission tomography/computed tomography for the diagnosis and management of patients with NETs.

Source: Future Oncology

DOI: 10.2217/fon-2017-0393

Authors: Amit Tirosh, Electron Kebebew

Institutions: National Institutes of Health, Tel Aviv University, National Cancer Institute, George Washington University

Language: English

Topic: Neuroendocrine Tumor Research Advances

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute