Work

Genetics of type 1 diabetes

Year: 2017

Type: review

Abstract: Type 1 diabetes (T1D) results from immune-mediated loss of pancreatic beta cells leading to insulin deficiency. It is the most common form of diabetes in children, and its incidence is on the rise. This article reviews the current knowledge on the genetics of T1D. In particular, we discuss the influence of HLA and non-HLA genes on T1D risk and disease progression through the preclinical stages of the disease, and the development of genetic scores that can be applied to disease prediction. Racial/ethnic differences, challenges and future directions in the genetics of T1D are also discussed.

Source: Pediatric Diabetes

DOI: 10.1111/pedi.12597

Authors: Maria J Redondo, Andrea K Steck, Alberto Pugliese

Institutions: Baylor College of Medicine, Texas Children's Hospital, University of Colorado Anschutz, University of Colorado Denver, University of Miami

Language: English

Topic: Diabetes and associated disorders

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: American Diabetes Association, Diabetes Research Institute Foundation, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases