Work

Accuracy of Models to Identify Lung Nodule Cancer Risk in the National Lung Screening Trial

Year: 2017

Type: article

Abstract: Lung Gene Expression Analysis web portal (11), we found that all the genes in Table 2 except CD97 were expressed in the human lung, but only MRPL44 (mitochondrial ribosomal protein L44), NOC3L (NOC3-like DNA replication regulator), and ABL1 (ABL protooncogene 1, nonreceptor tyrosine kinase) were expressed by lung immune cells.The small sample size of our case cohort and the lack of a replication cohort created significant limitations for this study and reflect the rarity of this disease.These data should be viewed as exploratory, pending replication in an independent cohort.However, our results suggest that FM may have a genetic basis and open the door for future investigations into the genetic underpinnings of this enigmatic disease.

Source: American Journal of Respiratory and Critical Care Medicine

DOI: 10.1164/rccm.201708-1632le

Authors: Viswam S. Nair, Vandana Sundaram, Manisha Desai, Michael K. Gould

Institutions: University of South Florida, Moffitt Cancer Center, Stanford Medicine, Stanford University, Kaiser Permanente

Language: English

Topic: Lung Cancer Diagnosis and Treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute