Work

Recent advances in the use of microfluidic technologies for single cell analysis

Year: 2017

Type: review

Abstract: The inherent heterogeneity in cell populations has become of great interest and importance as analytical techniques have improved over the past decades. With the advent of personalized medicine, understanding the impact of this heterogeneity has become an important challenge for the research community. Many different microfluidic approaches with varying levels of throughput and resolution exist to study single cell activity. In this review, we take a broad view of the recent microfluidic developments in single cell analysis based on microwell, microchamber, and droplet platforms. We cover physical, chemical, and molecular biology approaches for cellular and molecular analysis including newly emerging genome-wide analysis.

Source: The Analyst

DOI: 10.1039/c7an01346a

Authors: Travis W. Murphy, Qiang Zhang, Lynette B. Naler, Sai Ma, Chang Lu

Institution: Virginia Tech

Language: English

Topic: Microfluidic and Bio-sensing Technologies

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

Funders: National Human Genome Research Institute, National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering, Center for Scientific Review