Work

Establishment of induced pluripotent stem cell line (ZZUi010-A) from an Alzheimer's disease patient carrying an APP gene mutation

Year: 2017

Type: article

Abstract: Alzheimer's disease (AD) is one of the most common neurodegenerative disorders. Previous studies have identified mutations in several genes, such as amyloid precursor protein (APP), presenilin-1 (PSEN1), and presenilin-2 (PSEN2), in patients with early-onset (<65years) familial AD. Recently, a patient with an APP gene mutation was identified; the dermal fibroblasts of the patient were obtained and a line of induced pluripotent stem cells (iPSCs) was successfully generated using the Sendai-virus (SeV) delivery system. The iPSC line will be useful for further study of the pathomechanism and drug screening for AD.

Source: Stem Cell Research

DOI: 10.1016/j.scr.2017.10.025

Authors: Zhilei Wang, Pei Zhang, Yanlin Wang, Changhe Shi, Na Jing, Huifang Sun, Jing Yang, Yutao Liu, Xuejun Wen, Jin Zhang, Shoutao Zhang, Yuming Xu

Institutions: First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Tongji University, Virginia Commonwealth University, Shanghai East Hospital, First Affiliated Hospital Zhejiang University, Zhejiang University

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,360

Funders: National Natural Science Foundation of China, Zhengzhou University, Education Department of Henan Province, Science and Technology Department of Henan Province, First Affiliated Hospital of Zhengzhou University

Awards: G1734784790, G3280683047, G4403403120, G4847697638, G5056883063, G5459373459, G5462707618, G5569706557, CHIP蛋白参与脊髓小脑共济失调3型发病的分子机制及潜在治疗策略, G6723756946, G7881827450

OpenAlex ID: W2765849615

FWCI: 0.447

Cites: 3

Cited by: 10

Related to: 10