[ic‐02–04]: Axonal Density Is Associated With Subjective Cognitive Decline (scd) in Older Adults Assessed Using the Cognitive Change Index
Year: 2017
Type: article
Study design: Observational Study
Abstract: 1B-C).Although Tau was related to hippocampal volume among Ab+ (EC: r¼ -0.28, IT: r¼ -0.29), the strength of these relationships were smaller than the association between age and hippocampal volume in Ab+ (r¼ -0.52).Among Ab-, 5.3% of the total variance in memory was explained by age, EC Tau, IT Tau, and hippocampal volume, with age accounting for the most unique variance (DR 2 ¼ 1.7%).Among Ab+, 32.5% of the total variance in memory was explained by age, EC Tau, IT Tau, and hippocampal volume, with IT Tau accounting for the most unique variance (DR 2 ¼ 17.8%).Path analysis provided support for a model in which both EC and IT Tau are related to Ab whereas hippocampal volume is related to age.Furthermore, EC Tau is more proximal to Ab and IT Tau is more proximal to memory (Figure 2).Conclusions: These results suggest that hippocampal volume largely reflects non-Ab agerelated etiologies whereas Tau is more specific for early AD processes during the asymptomatic stage of AD.Our results are consistent with a model by which Ab exacerbates Tau in entorhinal cortex and catalyzes the spread of Tau into adjacent neocortex, which subsequently results in subtle memory impairment.
Source: Alzheimer s & Dementia
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2765869763