Work

Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors

Year: 2017

Type: article

Source: Bioorganic & Medicinal Chemistry

DOI: 10.1016/j.bmc.2017.10.042

Authors: William R. Shadrick, Peter J. Slavish, Sergio C. Chai, Brett Waddell, Michele Connelly, Jonathan A. Low, Cynthia Tallant, Brandon M. Young, Nagakumar Bharatham, Stefan Knapp, Vincent A. Boyd, Marie Morfouace, Martine F. Roussel, Taosheng Chen, Richard E. Lee, R. Kiplin Guy, Anang A. Shelat, Philip M. Potter

Institutions: St. Jude Children's Research Hospital, University of Oxford

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Wellcome Trust, National Institutes of Health, National Cancer Institute

Awards: A UK Hub to Catalyse Open Target Discovery., G1470995819, NORMAL & NEOPLASTIC GROWTH IN THE BRAIN, Cancer Center Support Grant (CCSG)

OpenAlex ID: W2765889348

FWCI: 1.899

Cites: 53

Cited by: 33

Related to: 10