Year: 2017
Type: review
Abstract: The realization that an intricate link exists between the metabolic state of immune cells and the nature of the elicited immune responses has brought a dramatic evolution to the field of immunology. We will focus on how metabolic reprogramming through the use of glycolysis and fatty-acid oxidation (sugar or fat) regulates the capacity of immune cells to mount robust and effective immune responses. We will also discuss how fine-tuning sugar and fat metabolism may be exploited as a novel immunotherapeutic strategy to fight viral infections or improve vaccine efficacy.
Source: Frontiers in Immunology
Language: English
Topic: Immune cells in cancer
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,801
Funders: amfAR, The Foundation for AIDS Research, California HIV/AIDS Research Program, University of Washington, Australian Centre for HIV and Hepatitis Virology Research, National Institutes of Health, Center for AIDS Research, University of Washington, Medical Research Council, National Health and Medical Research Council, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute on Drug Abuse, National Cancer Institute, National Institute of Allergy and Infectious Diseases
Awards: G1255407591, G1323885547, G2219438539, G2839755957, G3407947818, G3985073149, G4391827178, G4847806209, G6759634997, Characterizing HIV latent reservoir in vivo, G7791962275, G8035570451, G8245786331, G9000078127, G9000186388, G9000343736, University of Washington/Fred Hutch Center for AIDS Research, UCSF-Bay Area Center for AIDS Research, UAB Center for AIDS Research (CFAR), G929137571, G940002362, G94475886
OpenAlex ID: W2765913531