Year: 2017
Type: article
Study design: Observational Study
Abstract: function [Frontal Assessment Battery (FAB) and animal naming fluency].[Table1] Having AF was associated with an odds ratio of 2.17 for developing PSCI (95% CI: 1.03 -4.58; p¼0.041)] after adjusting for age, education, hypertension, large cortical and noncortical infarcts, WMH, and intracranial stenosis.When comparing subjects in the four conditions, AF+LCI subjects scored worse in MMSE, MoCA, and FAB than LCI Only and Nil subjects.AF Only subjects scored worse in 10-word immediate recall than Nil subjects.[Figure 1].Conclusions: AF is a significant risk factor for PSCI, and this effect is independent of acute infarct characteristics.The profile of PSCI in subjects with AF is characterized by deficits in episodic memory and executive function.Pathophysiological links between AF and PSCI, likely includes mechanisms other than infarcts such as cerebral hypoperfusion and neuroinflammation, may help to explain the observed impairments in these specific cognitive subdomains.
Source: Alzheimer s & Dementia
Institution: Johns Hopkins University
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2765937085