The tumor genome in human immunodeficiency virus–related head and neck cancer: Exploitable targets?
Year: 2017
Type: editorial
Abstract: In a small cohort of human immunodeficiency virus–related head and neck cancers, the majority are demonstrated to bear mutations in head and neck cancer–relevant genes, with some similarities to genomic profiles for human immunodeficiency virus–unrelated head and neck cancers. Although gene panels are not definitive for mutational signatures, the pattern of mutations is consistent with mutational signatures associated with the activity of the virally responsive APOBEC gene editing proteins. See also pages 84‐94.
Source: Cancer
DOI: 10.1002/cncr.31059
Author: Barbara Burtness
Institutions: Yale Cancer Center, Yale University
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2766008483