Gut Microbiota Perturbations in Reactive Arthritis and Postinfectious Spondyloarthritis
Year: 2017
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: Reactive arthritis (ReA) is an inflammatory disorder occurring several weeks after gastrointestinal or genitourinary tract infections. HLA-B27 positivity is considered a risk factor, although it is not necessarily predictive of disease incidence. Among nongenetic factors, the intestinal microbiome may play a role in disease susceptibility. The objective of this study was to characterize the gut microbiota and host gene interactions in ReA and postinfectious spondyloarthritis. METHODS: Adult subjects with peripheral spondyloarthritis and control subjects with preceding infections who did not develop arthritis were prospectively recruited from a geographic region with a high prevalence of ReA. Clinical variables, HLA status, and 16S ribosomal RNA gene sequencing of intestinal microbiota were analyzed. RESULTS: Subjects with ReA showed no significant differences from controls in gut bacterial richness or diversity. However, there was a significantly higher abundance of Erwinia and Pseudomonas and an increased prevalence of typical enteropathogens associated with ReA. Subjects with ultrasound evidence of enthesitis were enriched in Campylobacter, while subjects with uveitis and radiographic sacroiliitis were enriched in Erwinia and unclassified Ruminococcaceae, respectively; both were enriched in Dialister. Host genetics, particularly HLA-A24, were associated with differences in gut microbiota diversity irrespective of disease status. We identified several co-occurring taxa that were also predictive of HLA-A24 status. CONCLUSION: This is the first culture-independent study characterizing the gut microbial community in postinfectious arthritis. Although bacterial factors correlated with disease presence and clinical features of ReA, host genetics also appeared to be a major independent driver of intestinal community composition. Understanding of these gut microbiota-host genetic relationships may further clarify the pathogenesis of postinfectious spondyloarthritides.
Source: Arthritis & Rheumatology
DOI: 10.1002/art.40359
Institutions: New York University Langone Orthopedic Hospital, New York University, Icahn School of Medicine at Mount Sinai, Universidad Francisco Marroquín, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, Centro de Investigación Biomédica en Red, University of Pennsylvania, Louisiana State University Health Sciences Center New Orleans
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: National Psoriasis Foundation, Rheumatology Research Foundation, University of Pennsylvania, Ministerio de Economía y Competitividad, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Fogarty International Center, National Institute of Arthritis and Musculoskeletal and Skin Diseases
Awards: G1150758817, Translational Basic and Clinical Research Training in Rheumatology, Chronic disease clinical epidemiology training in guatemala and peru, The Role of Gut and Skin Microbiome in Psoriatic Arthritis, G2845741489, Transforming Genomics with 5 PB Big Omics Data Engine Cray CS300-AC Supercomputer, Human Gut Microbiome as Modulator of Drug Response in Inflammatory Arthritis, Identification of Early Psoriatic Arthritis, Lung Microbiome and Inflammation in Early COPD
OpenAlex ID: W2766399591