Work

Continuous directed evolution of aminoacyl-tRNA synthetases

Year: 2017

Type: article

Source: Nature Chemical Biology

DOI: 10.1038/nchembio.2474

Authors: David I Bryson, Chenguang Fan, Li-Tao Guo, Corwin Miller, Dieter Söll, David R Liu

Institutions: Harvard University, University of Arkansas at Fayetteville, Yale University, Broad Institute, Howard Hughes Medical Institute

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Howard Hughes Medical Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Institute of Biomedical Imaging and Bioengineering

Awards: Directed Evolution of Improved Orthogonal Aminoacyl-tRNASynthetases Through Phage Assisted Continuous Evolution (PACE), Studies of Transfer RNA, Studies of Transfer RNA, Expanding the genetic code in Salmonella, Continuous Evolution of Proteins with Novel Therapeutic Potential, Integrating Chemistry and Evolution to Illuminate Biology and Enable Novel Therapeutics

OpenAlex ID: W2766423195

FWCI: 8.49

Cites: 46

Cited by: 273

Related to: 10