Work

HDAC8 regulates long-term hematopoietic stem-cell maintenance under stress by modulating p53 activity

Year: 2017

Type: article

Abstract: -deficient mice challenged with serial 5-fluorouracil treatment. This hypersensitivity to hematopoietic ablation was completely rescued by inactivation of p53. Altogether, these results indicate that HDAC8 functions to modulate p53 activity to ensure LT-HSC maintenance and cell survival under stress.

Source: Blood

DOI: 10.1182/blood-2017-03-771386

Authors: Wei-Kai Hua, Jing Qi, Qi Cai, Emily Carnahan, Maria Ayala Ramirez, Ling Li, Guido Marcucci, Ya-Huei Kuo

Institutions: City Of Hope National Medical Center, City of Hope, Beckman Research Institute

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute

Awards: HDAC8 Mediated Regulation of Acute Myeloid Leukemia Pathogenesis and Maintenance, Cancer Center Support Grant

OpenAlex ID: W2766590494

FWCI: 4.131

Cites: 58

Cited by: 56

Related to: 10