Year: 2018
Type: article
Abstract: Tic suppression is the primary target of tic disorder treatment, but factors that influence voluntary tic inhibition are not well understood. Several studies using the Tic Suppression Task have demonstrated significant inter-individual variability in tic suppressibility but have individually been underpowered to address correlates of tic suppression. The present study explored patterns and clinical correlates of reward-enhanced tic suppression in youth with tic disorders using a large, pooled dataset. Individual-level data from nine studies using the Tic Suppression Task were pooled, yielding a sample of 99 youth with tic disorders. Analyses examined patterns of tic suppressibility and the relationship between tic suppressibility and demographic and clinical characteristics. A large majority of youth demonstrated a high degree of tic suppression, but heterogeneous patterns of tic suppressibility were also observed. Better tic suppressibility was related to older age and more frequent tics but unrelated to other clinical variables, including presence of psychiatric comorbidity, psychotropic medication status, tic and premonitory urge severity, and self-rated tic suppressibility. The mechanisms underlying the observed heterogeneity in reward-enhanced tic suppressibility warrant further investigation. The Tic Suppression Task is a promising method for testing mechanistic hypotheses related to tic suppression.
Source: Frontiers in Psychiatry
Language: English
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: gold
Estimated APC paid: $3,801
Funders: Michael J. Fox Foundation for Parkinson's Research, Sanofi, American Academy of Neurology, Foundation for Barnes-Jewish Hospital, Tourette Association of America, Neurocrine Biosciences, National Institutes of Health, Center for California Studies, California State University, Brown Institute for Brain Science, Sanofi Genzyme, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke
Awards: Training Investigators in Neuroimaging and Neuropsychiatry of Movement Disorders, PREDICTING OUTCOME IN CHILDREN WITH TIC DISORDERS USING NEUROIMAGING DATA, PREDICTING OUTCOME IN CHILDREN WITH NEW-ONSET TICS USING NEUROIMAGING DATA, The New Tics Study: A Novel Approach to Pathophysiology and Cause of Tic Disorders, G7442208703
OpenAlex ID: W2766601159