Work

Synthetic Lethal Vulnerabilities in KRAS-Mutant Cancers

Year: 2017

Type: preprint

Abstract: -mutant cancers, including the results of numerous functional genetic screens aimed at identifying KRAS synthetic lethal targets. Importantly, many of these vulnerabilities may represent tractable therapeutic opportunities.

Source: Cold Spring Harbor Perspectives in Medicine

DOI: 10.1101/cshperspect.a031518

Authors: Andrew J. Aguirre, William C. Hahn

Institutions: Broad Institute, Brigham and Women's Hospital, Harvard University, Dana-Farber Cancer Institute, Massachusetts Institute of Technology

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Harvard Catalyst, Hope Funds for Cancer Research, National Cancer Institute, National Center for Advancing Translational Sciences

Awards: Dana Farber/ Harvard Cancer Center SPORE in Gastrointestinal Cancer, G1470284823, G1682396898, G2185853629, G3615943839, Protein Kinase Therapeutic Targets for Non-Small Cell Lung Carcinoma, G7060033699, Regulation and function of IKKe in breast cancer initiation and maintenance

OpenAlex ID: W2766798501

Cites: 136

Cited by: 90

Related to: 10