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Cognitive Decline in Neuronal Aging and Alzheimer's Disease: Role of NMDA Receptors and Associated Proteins

Year: 2017

Type: article

Abstract: Molecular changes associated with neuronal aging lead to a decrease in cognitive capacity. Here we discuss these alterations at the level of brain regions, brain cells, and brain membrane and cytoskeletal proteins with an special focus in NMDA molecular changes through aging and its effect in cognitive decline and Alzheimer disease. Here, we propose that some neurodegenerative disorders, like Alzheimer's disease (AD), are characterized by an increase and acceleration of some of these changes.

Source: Frontiers in Neuroscience

DOI: 10.3389/fnins.2017.00626

Authors: Jesús Avila, María Llorens-Martín, Noemí Pallas-Bazarra, Marta Bolós, Juan R. Perea, Alberto Rodríguez-Matellán, Félix Hernández

Institutions: Consejo Superior de Investigaciones Científicas, Instituto de Salud Carlos III, Biomedical Research Networking Center on Neurodegenerative Diseases, Centro de Investigación Biomédica en Red, Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801

Funders: Ministerio de Economía y Competitividad, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Instituto de Salud Carlos III

Award: G2743672107

OpenAlex ID: W2766813403

FWCI: 2.348

Cites: 112

Cited by: 59

Related to: 10