Genetic, Immunologic, and Environmental Basis of Sarcoidosis
Year: 2017
Type: review
Abstract: Sarcoidosis is a multisystem disease with tremendous heterogeneity in disease manifestations, severity, and clinical course that varies among different ethnic and racial groups. To better understand this disease and to improve the outcomes of patients, a National Heart, Lung, and Blood Institute workshop was convened to assess the current state of knowledge, gaps, and research needs across the clinical, genetic, environmental, and immunologic arenas. We also explored to what extent the interplay of the genetic, environmental, and immunologic factors could explain the different phenotypes and outcomes of patients with sarcoidosis, including the chronic phenotypes that have the greatest healthcare burden. The potential use of current genetic, epigenetic, and immunologic tools along with study approaches that integrate environmental exposures and precise clinical phenotyping were also explored. Finally, we made expert panel-based consensus recommendations for research approaches and priorities to improve our understanding of the effect of these factors on the health outcomes in sarcoidosis.
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Immunologic and Molecular Phenotypes in AATD and Sarcoidosis, Investigation of microbial hetergeneity to sarcoidosis and AAT clinical outcome, T cell Epitope Discovery in Sarcoidosis, Genetic Risk for Granulomatous Interstitial Lung Disease, GRADS Cooperative Research Project: JHU Clinical Center, Characterization of European American and African American Sarcoidosis via Immunogenetics, Mentoring in Translational Research in Interstitial Lung Diseases
OpenAlex ID: W2766982226