Work

XtalFluor-E® mediated proto-functionalization of N -vinyl amides: access to N -acetyl N , O -acetals

Year: 2017

Type: article

Abstract: XtalFluor-E® has been extensively used in a broad range of reactions in the past few years. Here we report its use with protic nucleophiles in a catalytic manner for the in situ generation of protons that lead to the proto-functionalization of activated olefins. Utilizing the latter protocol, proto etherification of enamides gives rise to N,O-acetals in nearly quantitative yields.

Source: Organic & Biomolecular Chemistry

DOI: 10.1039/c7ob02283b

Authors: Y. Yi, H. Gholami, M. G. Morrow, B. Borhan

Institution: Michigan State University

Language: Hebrew

Topic: Fluorine in Organic Chemistry

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: G1495357881, Predicted Reaction Discovery and Application of Catalytic Asymmetric Alkene Halogenations