The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1
Year: 2017
Type: article
Abstract: Finally, genetic ablation or pharmacological blockade of Nox1 in human endothelial cells attenuated TSP1-mediated ROS generation, restored cell cycle progression, and protected against senescence. Together, our results provide insights into the functional interplay between TSP1 and Nox1 in the regulation of endothelial senescence and suggest potential targets for controlling the aging process at the molecular level.
Source: Science Signaling
Institution: University of Pittsburgh
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1592428837, G1784103360, G2135684065, Bioengineering Tracheas Through Targeting Activated CD47, Reactive Oxygen Species in Vascular Disease, G2817481816, G2968840033, Cell Therapy for the Treatment of Acute Respiratory Distress Syndrome, G3148665142, Platelet TSP1 Mediates Vascular Disease and pulmonary hypertension in Sickle Cell, G3299970860, G3394685722, TSP1-CD47 in Promotion of PAH-Associated Vasoconstriction and Vascular Overgrowth, G3692364373, G3739559729, The Roles of Nox1, EBP50 and Ask1 in Right Ventricular Hypertrophy, G4060767945, G4742193112, Therapeutic Targeting of Vascular Subphenotypes of Lung Disease, G5356856232, Predoctoral Training in Pharmacological Sciences, G6588018639, TSP-1 and ROS: CD47 and SIRP-alpha as Mediators of Vascular Dysfunction, G7563002759, G7602727422, G8299025695, G832719042, Aging of Mesenchymal Stem Cells Missing Link in IPF, Translational Training Program in Pulmonary Biology and Medicine, Antidote for inhaled CO poisoning based on mutationally engineered neuroglobin, Omics, mice and men: Development of precision transfusion medicine, Training in Translational Research in Pulmonary Vascular Biology
OpenAlex ID: W2767034640