Work

In search of regulatory circuits that control the biological activity of vitamin D

Year: 2017

Type: article

Abstract: Although the cytochrome P450 CYP27B1 plays a critical role in vitamin D biology, the molecular mechanisms involved in regulation of CYP27B1 have remained undefined. A new study has identified a kidney-specific control module distal to the Cyp27b1 gene that mediates the basal activity and hormonal regulation of Cyp27b1 . This work provides a novel mechanism indicating differential regulation of Cyp27b1 in renal and non-renal cells and has implications for vitamin D biology in multiple sclerosis and perhaps other autoimmune diseases as well.

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.h117.806901

Author: Sylvia Christakos

Institutions: Rutgers, The State University of New Jersey, Rutgers New Jersey Medical School

Language: English

Topic: Vitamin D Research Studies

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,430