Metabolic strategies of melanoma cells: Mechanisms, interactions with the tumor microenvironment, and therapeutic implications
Year: 2017
Type: review
Abstract: Melanomas are metabolically heterogeneous, and they are able to adapt in order to utilize a variety of fuels that facilitate tumor progression and metastasis. The significance of metabolism in melanoma is supported by growing evidence of impact on the efficacy of contemporary therapies for this disease. There are also data to support that the metabolic phenotypes of melanoma cells depend upon contributions from both intrinsic oncogenic pathways and extrinsic factors in the tumor microenvironment. This review summarizes current understanding of the metabolic processes that promote cutaneous melanoma tumorigenesis and progression, the regulation of cancer cell metabolism by the tumor microenvironment, and the impact of metabolic pathways on targeted and immune therapies.
Source: Pigment Cell & Melanoma Research
DOI: 10.1111/pcmr.12661
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: bronze
Funders: Conquer Cancer Foundation, Cancer Prevention and Research Institute of Texas, Melanoma Research Alliance, Dr. Miriam and Sheldon G. Adelson Medical Research Foundation, American Society of Clinical Oncology, National Institutes of Health, University of Texas MD Anderson Cancer Center, National Cancer Institute, National Center for Advancing Translational Sciences
Awards: Center for Clinical and Translational Sciences (CCTS), Exploiting molecular and metabolic dependencies to optimize personalized therapeutic approaches for melanomas, Research Training in Academic Medical Oncology, G3549828030, G4543436975, Targeting The Glycolysis Pathway To Overcome Resistance To Cancer Immunotherapy, G557517774, G5639774319, Center for Clinical and Translational Sciences (CCTS), A novel mitochondrial inhibitor to overcome resistance to MAPK inhibition, G7436411625, G816327597, G9000100142, Human metabolic variation as a window into cancer initiation and progression, A High-Throughput Model for Human Melanoma, The University of Texas M. D. Anderson Cancer Center SPORE in Melanoma
OpenAlex ID: W2767190680