Genetic and neuronal regulation of sleep by neuropeptide VF
Year: 2017
Type: article
Abstract: Sleep is an essential and phylogenetically conserved behavioral state, but it remains unclear to what extent genes identified in invertebrates also regulate vertebrate sleep. RFamide-related neuropeptides have been shown to promote invertebrate sleep, and here we report that the vertebrate hypothalamic RFamide neuropeptide VF (NPVF) regulates sleep in the zebrafish, a diurnal vertebrate. We found that NPVF signaling and npvf-expressing neurons are both necessary and sufficient to promote sleep, that mature peptides derived from the NPVF preproprotein promote sleep in a synergistic manner, and that stimulation of npvf-expressing neurons induces neuronal activity levels consistent with normal sleep. These results identify NPVF signaling and npvf-expressing neurons as a novel vertebrate sleep-promoting system and suggest that RFamide neuropeptides participate in an ancient and central aspect of sleep control.
Source: eLife
DOI: 10.7554/elife.25727
Authors: Daniel A Lee, Andrey Andreev, Thai V Truong, Audrey Chen, Andrew J Hill, Grigorios Oikonomou, Uyen Pham, Young K Hong, Steven Tran, Laura Glass, Viveca Sapin, Jae Engle, Scott E Fraser, David A Prober
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,500
Awards: Mechanisms of Sleep Regulation by EGFR-Mediated Neural and Molecular Circuits, Regulation of Zebrafish Sleep by Neuromedin U, Hypocretin and Locus Ceruleus Interactions in Zebrafish Development and Behavior, Dynamic mapping of the complete synaptome using recombinant probes, G4128065622, Neuropeptidergic Regulation of Zebrafish Sleep, Regulation of Sleep and Circadian Behaviors by TGF-alpha Signaling, Circadian Regulation of Zebrafish Sleep by Melatonin, Role of Prokineticin 2 in Regulating Sleep in Zebrafish, G9000353668
OpenAlex ID: W2767264485