Qlif-20. Skin Care Products Compatible With Tumor Treating Fields
Year: 2017
Type: conference-abstract
Abstract: Low intensity, intermediate frequency, alternating electric fields (TTFields) are approved for the treatment of patients with glioblastoma multiforme (GBM). TTFields are applied continuously using a set of four arrays placed on the skin. The main TTFields-related adverse event is mild-moderate dermatitis occurring under the arrays, which is primarily caused by long-term exposure to irritants and may be exacerbated by local hyperhidrosis and occlusion. Strategies that mitigate skin irritation may improve patients’ quality of life and compliance with TTFields. Antiperspirants, moisturizing creams, antibiotics, and skin barriers have been anecdotally reported to alleviate factors related to TTFields-related skin irritation. Nonetheless, not all aforementioned products are compatible with TTFields as some may increase electrical impedance, which may lead to increased temperatures beneath the arrays. This study investigated the effect of applying 40 commercially available skin care products on electrical impedance during TTFields application, using a rat model. In these experiments, 200 kHz TTFields were applied using ceramic disks and hydrogels identical to those used with human arrays. Changes in impedance caused by applying each product on the rat skin were measured using the Optune device and an LCR meter system. The review identified a set of skin care products from all 4 groups that do not lead to a significant change in the impedance. These results suggest that local application of TTFields-compatible skin care products could maintain normal electrical resistance of the scalp-array interface, thereby allowing optimal delivery of TTFields to the brain. These products should be prospectively investigated for their potential role in minimizing TTFields–related skin irritation.
Source: Neuro-Oncology
Institution: Memorial Sloan Kettering Cancer Center
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2767368964