Work

The Centiloid Project: Standardizing quantitative amyloid plaque estimation by PET

Year: 2014

Type: article

Abstract: Although amyloid imaging with PiB-PET ([C-11]Pittsburgh Compound-B positron emission tomography), and now with F-18-labeled tracers, has produced remarkably consistent qualitative findings across a large number of centers, there has been considerable variability in the exact numbers reported as quantitative outcome measures of tracer retention. In some cases this is as trivial as the choice of units, in some cases it is scanner dependent, and of course, different tracers yield different numbers. Our working group was formed to standardize quantitative amyloid imaging measures by scaling the outcome of each particular analysis method or tracer to a 0 to 100 scale, anchored by young controls (≤ 45 years) and typical Alzheimer's disease patients. The units of this scale have been named "Centiloids." Basically, we describe a "standard" method of analyzing PiB PET data and then a method for scaling any "nonstandard" method of PiB PET analysis (or any other tracer) to the Centiloid scale.

Source: Alzheimer s & Dementia

DOI: 10.1016/j.jalz.2014.07.003

Authors: William E. Klunk, Robert A. Koeppe, Julie C. Price, Tammie L. Benzinger, Michael D. Devous, William J. Jagust, Keith A. Johnson, Chester A. Mathis, Davneet Minhas, Michael J. Pontecorvo, Christopher C. Rowe, Daniel M. Skovronsky, Mark A. Mintun

Institutions: University of Pittsburgh, Massachusetts General Hospital, University of Michigan, Washington University in St. Louis, The University of Texas Southwestern Medical Center, University of California, Berkeley, Avid Radiopharmaceuticals (United States), Austin Hospital, Austin Health

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: University of Pittsburgh, GE Healthcare, Avid Radiopharmaceuticals, National Institute on Aging

Awards: The role of astrogliosis in aging and the pathological and clinical progression of Alzheimer's Disease, Roles of Gray Matter Brain Aging and Small Vessel Disease in AD Pathophysiology, Alzheimer's Disease Research Center, Dominantly Inherited Alzheimer Network, Healthy Aging and Senile Dementia, Dominantly Inherited Alzheimer Network, AMYLOID PATHOLOGY AND COGNITION IN NORMAL ELDERLY, Neural and Biochemical Mechanisms of Cognitive Aging, Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study

OpenAlex ID: W2124030567

FWCI: 16.32

Cites: 39

Cited by: 1,373

Related to: 10