Year: 2017
Type: conference-abstract
Abstract: Circadian rhythms are self-sustainable endogenous 24 hours oscillations, present in every living system and cell, driving daily cycles of biological process, including cell division and metabolism. Circadian rhythm disruption by shift work or core clock genes dysfunction is associated with high risk of tumor development, indicating a putative tumor-suppressive role of circadian rhythm. Using a subpopulation of stem-like cells, coming from human glioblastoma displaying cellular hierarchies, we characterized the role of core clock genes in these stem-like cells. We found that circadian rhythm transcriptional factors Clock and Bmal1 in glioblastoma stem-like cells (GSC) is required for the growth of GSC in vitro and in vivo. Disruption of canonical circadian pathway components produce anti-brain tumor effects, including decreased proliferation, impaired self-renew, increased cell apoptosis and depletion of GSC. Loss of Bmal1 and Clock led to mitochondrial respiration dysregulation and impaired the tricarboxylic acid cycle by regulating genes and enzymes expression in this process. Our finding established a novel role for the core circadian rhythm genes in glioblastoma stem-like cells.
Source: Neuro-Oncology
Authors: Zhen Dong, Guoxin Zhang, Qiulian Wu, Jeremy Rich
Institution: University of California San Diego
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2767566392