Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance
Work
Year: 2018
Type: article
Abstract: Although PARP inhibitors (PARPi) target homologous recombination defective tumours, drug resistance frequently emerges, often via poorly understood mechanisms. Here, using genome-wide and high-density... more
Source: Nature Communications
Institutions Institute of Cancer Research, Bulgarian Academy of Sciences, Institute of Molecular Biology, University of Washington, Breast Cancer Now +4 more
Cites: 58
Cited by: 378
Related to: 10
FWCI: 18.71
Citation percentile (by year/subfield): 100
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Sustainable Development Goal Good health and well-being
Open Access status: gold
APC paid (est): $4,607