Year: 2016
Type: dissertation
Abstract: Innate T cells, which include PLZF+ T cells and innate memory CD8 SPs, represent a unique lineage of T cells that are pre-activated and rapidly respond to antigen. Although the role of Notch in early T cell development is well-established, its function in late T cell development, when innate T cells arise, is unclear. Here, we report that CD4-Cre-mediated intracellular Notch1 expression (ICN1) increased the non-cell autonomous development of innate memory CD8 SPs. ICN1-expression also increased the frequency of NKT2 cells and number of V6 γδ T cells in the thymus, which are specific PLZF-expressing innate T cell subsets suggested to drive innate memory CD8 SP development through IL-4 secretion. Collectively, my data demonstrates that Notch signaling is an important regulator of innate T cell development and emphasizes its role in late T cell development.
Source: TSpace (University of Toronto)
Author: Christopher James Gunst
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2767691750