Transcriptome-wide association study of inflammatory biologic age
Year: 2017
Type: article
Study design: Observational Study
Abstract: ), 302 genes were positively associated and 146 genes were negatively associated. Pathway analysis among the identified genes highlighted the NOD-like receptor signaling and ubiquitin mediated proteolysis pathways. In summary, we identified 448 genes that were significantly associated with inflammatory biologic age. Future functional characterization may identify molecular interventions to delay aging and prolong healthspan in older adults.
Source: Aging
Language: English
Subfield: Aging
Domain: Life Sciences
Open Access status: green
Awards: Circulating Epigenetic Biomarkers for Personalized Cardiovascular Disease Prevention, G278200998, G3405256882, AFGen Consortium: Atrial Fibrillation Genomics to Functional Analyses, Aging and Inflammation: Longitudinal Markers and Genetics in the Framingham Study, G5164707915, Framingham: Inflammation, Genes & Cardiovascular Disease, The Framingham Heart Study, Novel multi-omics approach to the biology of healthy aging: Framingham Study, Boston University Clinical and Translational Science Institute, IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL
OpenAlex ID: W2767775049