Work

The opioid epidemic: a central role for the blood brain barrier in opioid analgesia and abuse

Year: 2017

Type: article

Abstract: Opioids are currently the primary treatment method used to manage both acute and chronic pain. In the past two to three decades, there has been a surge in the use, abuse and misuse of opioids. The mechanism by which opioids relieve pain and induce euphoria is dependent on the drug crossing the blood-brain barrier and accessing the central nervous system. This suggests the blood brain barrier plays a central role in both the benefits and risks of opioid use. The complex physiological responses to opioids that provide the benefits and drive the abuse also needs to be considered in the resolution of the opioid epidemic.

Source: Fluids and Barriers of the CNS

DOI: 10.1186/s12987-017-0080-3

Authors: Charles P. Schaefer, Margaret E. Tome, Thomas P. Davis

Institution: University of Arizona

Language: English

Topic: Barrier Structure and Function Studies

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,390