Year: 2017
Type: article
Abstract: High rates of relapse to drug use during abstinence is a defining feature of human drug addiction. This clinical scenario has been studied at the preclinical level using different animal models in which relapse to drug seeking is assessed after cessation of operant drug self-administration in rodents and monkeys. In our Society for Neuroscience (SFN) session entitled "Circuit and Synaptic Plasticity Mechanisms of Drug Relapse," we will discuss new developments of our understanding of circuits and synaptic plasticity mechanisms of drug relapse from studies combining established and novel animal models with state-of-the-art cellular, electrophysiology, anatomical, chemogenetic, and optogenetic methods. We will also discuss the translational implications of these new developments. In the mini-review that introduces our SFN session, we summarize results from our laboratories on behavioral, cellular, and circuit mechanisms of drug relapse within the context of our session.
Source: Journal of Neuroscience
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Awards: G1250591687, G3265210459, Decision-Making Dysfunction and Chronic Cocaine, G5619543332, Synaptic mechanisms maintaining persistent cocaine craving, G7537053416, Dopamine and Glutamate Receptor Interactions, G8900237735, Individual Differences & Cocaine Effects on Impulsive Choice in Rat, Glutamate receptor plasticity underlying incubation of methamphetamine craving, Cocaine-induced adaptation in NMDA receptors
OpenAlex ID: W2767890607