Work

Chemical Biology of H 2 S Signaling through Persulfidation

Year: 2017

Type: review

Abstract: Signaling by H 2 S is proposed to occur via persulfidation, a posttranslational modification of cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for understanding the physiological and pharmacological effects of H 2 S. Due to the inherent instability of persulfides, their chemistry is understudied. In this review, we discuss the biologically relevant chemistry of H 2 S and the enzymatic routes for its production and oxidation. We cover the chemical biology of persulfides and the chemical probes for detecting them. We conclude by discussing the roles ascribed to protein persulfidation in cell signaling pathways.

Source: Chemical Reviews

DOI: 10.1021/acs.chemrev.7b00205

Authors: Milos R. Filipovic, Jasmina Zivanovic, Beatriz Alvarez, Ruma Banerjee

Institutions: Centre National de la Recherche Scientifique, Institut de Biochimie et Génétique Cellulaires, Universidad de la República de Uruguay, University of Michigan, Michigan Medicine

Language: English

Topic: Sulfur Compounds in Biology

Subfield: Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green