Work

Matrix-binding checkpoint immunotherapies enhance antitumor efficacy and reduce adverse events

Year: 2017

Type: article

Abstract: T cells, resulting in a delay of distant tumor growth as well. This simple and translatable approach of engineered ECM-binding Abs may present a viable and safer approach in checkpoint blockade.

Source: Science Translational Medicine

DOI: 10.1126/scitranslmed.aan0401

Authors: Jun Ishihara, Kazuto Fukunaga, Ako Ishihara, Hans M. Larsson, Lambert Potin, Peyman Hosseinchi, Gabriele Galliverti, Melody A. Swartz, Jeffrey A. Hubbell

Institutions: University of Chicago, École Polytechnique Fédérale de Lausanne, Tokyo Institute of Technology

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: European Commission

OpenAlex ID: W2768026634

FWCI: 7.111

Cites: 49

Cited by: 158

Related to: 10