Cognitive Development One Year After Infantile Critical Pertussis*
Year: 2017
Type: article
Study design: Observational Study
Abstract: OBJECTIVES: Pertussis can cause life-threatening illness in infants. Data regarding neurodevelopment after pertussis remain scant. The aim of this study was to assess cognitive development of infants with critical pertussis 1 year after PICU discharge. DESIGN: Prospective cohort study. SETTING: Eight hospitals comprising the Eunice Kennedy Shriver National Institute for Child Health and Human Development Collaborative Pediatric Critical Care Research Network and 18 additional sites across the United States. PATIENTS: Eligible patients had laboratory confirmation of pertussis infection, were less than 1 year old, and were admitted to the PICU for at least 24 hours. INTERVENTIONS: The Mullen Scales of Early Learning was administered at a 1-year follow-up visit. Functional status was determined by examination and parental interview. MEASUREMENTS AND MAIN RESULTS: Of 196 eligible patients, 111 (57%) completed the Mullen Scales of Early Learning. The mean scores for visual reception, receptive language, and expressive language domains were significantly lower than the norms (p < 0.001), but not fine and gross motor domains. Forty-one patients (37%) had abnormal scores in at least one domain and 10 (9%) had an Early Learning Composite score 2 or more SDs below the population norms. Older age (p < 0.003) and Hispanic ethnicity (p < 0.008) were associated with lower mean Early Learning Composite score, but presenting symptoms and PICU course were not. CONCLUSIONS: Infants who survive critical pertussis often have neurodevelopmental deficits. These infants may benefit from routine neurodevelopmental screening.
Source: Pediatric Critical Care Medicine
Authors: John T. Berger, Michele E. Villalobos, Amy E. Clark, Richard Holubkov, Murray M. Pollack, Robert A. Berg, Joseph A. Carcillo, Heidi Dalton, Rick Harrison, Kathleen L. Meert, Christopher J. L. Newth, Thomas P. Shanley, David L. Wessel, Kanwaljeet J. S. Anand, Jerry J. Zimmerman, Ronald C. Sanders, Teresa Liu, Jeri S. Burr, Douglas F. Willson, Allan Doctor, J. Michael Dean, Tammara L. Jenkins, Carol E. Nicholson
Institutions: Children's National, University of North Carolina at Chapel Hill, University of Utah, Children's Hospital of Philadelphia, Children's Hospital of Pittsburgh, Phoenix Children's Hospital, University of California, Los Angeles, Mattel Children's Hospital, Children's Hospital of Michigan, Children's Hospital Los Angeles, University of Michigan, C. S. Mott Children's Hospital, Le Bonheur Children's Hospital, Seattle Children's Hospital, Arkansas Children's Hospital, Virginia Commonwealth University, St. Louis Children's Hospital, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Language: English
Subfield: Microbiology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Awards: Neurodevelopmental Outcome after Cardiac Intensive Care, G1223667318, G1328420516, Collaborative Pediatric Critical Care Research Network, Data Coordinating Center for the Collaborative Pediatric Critical Care Research Network, Pediatric Critical Care Research Network at Children's Hospital of Philadelphia, Controlled Trial of Two Lung Protective Ventilation Modes in Acute Lung Injury, Collaborative Pediatric Critical Care Research Network (CPCCRN) at Children's National, Neurotransmitter Injury Mechanisms in Developing Brain, Predicting Morbidity from Pediatric Critical Care, Collaborative Pediatric Critical Care Research Network, Collaborative Pediatric Research Critical Care Network(U10), Pediatric Critical Care Research Network at Children's Hospital of Philadelphia, 1st Tier Drugs+Theophylline in Pediatric Severe Asthma, Collaborative Pediatric Critical Care Research Network - Clinical Site, Collaborative Pediatric Critical Care Research Network At Children's Hospital of
OpenAlex ID: W2768037868