Work

Aldehyde dehydrogenase 1 A1 is expressed by cancer stem cells and mediates chemoresistance in human glioblastoma

Year: 2012

Type: dissertation

Abstract: Due to the “cancer stem cell” paradigm a cellular subset with stem like characteristics is able to escape therapy and to induce tumor re-growth. Recurrence also accounts for the devastating prognosis of glioblastoma (GBM), the most common and most aggressive primary brain tumor. Despite extensive therapy, the prognosis for GBM patients remains poor. Hence, there is a need to characterize these resistant cell populations in order to identify appropriate biomarkers and therapeutic targets in human GBMs. The data of this thesis demonstrate that the enzyme aldehyde dehydrogenase 1 A1 (ALDH1A1) is not only a marker of therapy resistant GBM cells with stem cell characteristics, but also a direct mediator of chemoresistance. Therefore ALDH1A1 serves as a feasible predictor of clinical outcome and a potential therapeutic target in the future treatment of human malignancies.

Source: mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich)

Author: Andrea Schäfer

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2768160901

Cites: 146

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Related to: 10