Cord Metabolic Profiles in Obese Pregnant Women: Insights Into Offspring Growth and Body Composition
Year: 2017
Type: article
Abstract: Context: Offspring exposed in utero to maternal obesity have an increased risk of later obesity; however, the underlying mechanisms remain unknown. Objective: To assess the effect of an antenatal lifestyle intervention in obese women on the offspring's cord blood metabolic profile and to examine associations of the cord blood metabolic profile with maternal clinical characteristics and offspring anthropometry at birth and age 6 months. Design: Randomized controlled trial and cohort study. Setting: The UK Pregnancies Better Eating and Activity Trial. Participants: Three hundred forty-four mother-offspring pairs. Intervention: Antenatal behavioral lifestyle (diet and physical activity) intervention. Main Outcome Measures: Targeted cord blood metabolic profile, including candidate hormone and metabolomic analyses. Results: The lifestyle intervention was not associated with change in the cord blood metabolic profile. Higher maternal glycemia, specifically fasting glucose at 28 weeks gestation, had a linear association with higher cord blood concentrations of lysophosphatidylcholines (LPCs) 16.1 (β = 0.65; 95% confidence interval: 0.03 to 0.10) and 18.1 (0.52; 0.02 to 0.80), independent of the lifestyle intervention. A principal component of cord blood phosphatidylcholines and LPCs was associated with infant z scores of birth weight (0.04; 0.02 to 0.07) and weight at age 6 months (0.05; 0.00 to 0.10). Cord blood insulin growth factor (IGF)-1 and adiponectin concentrations were positively associated with infant weight z score at birth and at 6 months. Conclusions: Concentrations of LPCs and IGF-1 in cord blood are related to infant weight. These findings support the hypothesis that susceptibility to childhood obesity may be programmed in utero, but further investigation is required to establish whether these associations are causally related.
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: The UPBEAT RCT mother-child study. Stratifying and treating obese pregnant women to prevent adverse pregnancy, perinatal and longer term outcomes., G1093531541, G1563105402, G2000816325, G2473961061, G2566874064, G3207356259, NIHR Senior Investigator Award, NIHR Senior Investigator Award, Improving pregnancy outcome in obese women, G393177772, G5056894301, RENEWAL: Maternal and epigenetic determinants of cardiovascular structure and function, NIHR Senior Investigator Award, G5605571342, G5702163051, Epigenetic biomarkers and determinants of cardiovascular risk in children, G6219046052, G6470444756, Lifecourse Determinants of Bone and Joint Disease, NIHR Senior Investigator Award, Assessment of LifeLab Southampton: engaging teenagers in increasing their interest in science to improve their health behaviours, Nutrition, Development and Lifelong Health: Studies in European Populations, Maternal vitamin B12, folic acid and homocysteine as determinants of gestational diabetes, fetal growth and intergenerational programming of diabesity, G8537530744, Long-term effects of early nutrition on later health
OpenAlex ID: W2768194049