Ovarian cancer early detection by circulating CA 125 in the context of anti‐ CA 125 autoantibody levels: Results from the EPIC cohort
Year: 2017
Type: article
Study design: Observational Study
Abstract: CA125 is the best ovarian cancer early detection marker to date; however, sensitivity is limited and complementary markers are required to improve discrimination between ovarian cancer cases and non‐cases. Anti‐CA125 autoantibodies are observed in circulation. Our objective was to evaluate whether these antibodies (1) can serve as early detection markers, providing evidence of an immune response to a developing tumor, and (2) modify the discriminatory capacity of CA125 by either masking CA125 levels (resulting in lower discrimination) or acting synergistically to improve discrimination between cases and non‐cases. We investigated these objectives using a nested case–control study within the European Prospective Investigation into Cancer and Nutrition cohort (EPIC) including 250 cases diagnosed within 4 years of blood collection and up to four matched controls. Circulating CA125 antigen and antibody levels were quantified using an electrochemiluminescence assay. Adjusted areas under the curve (aAUCs) by 2‐year lag‐time intervals were calculated using conditional logistic regression calibrated toward the absolute risk estimates from a pre‐existing epidemiological risk model as an offset‐variable. Anti‐CA125 levels alone did not discriminate cases from controls. For cases diagnosed <2 years after blood collection, discrimination by CA125 antigen was suggestively higher with higher anti‐CA125 levels (aAUC, highest antibody tertile: 0.84 [0.76–0.92]; lowest tertile: 0.76 [0.67–0.86]; phet = 0.06). We provide the first evidence of potentially synergistic discrimination effects of CA125 and anti‐CA125 antibodies in ovarian early detection. If these findings are replicated, evaluating CA125 in the context of its antibody may improve ovarian cancer early detection.
Source: International Journal of Cancer
DOI: 10.1002/ijc.31164
Authors: Renée T. Fortner, Helena Schock, Charlotte Le Cornet, Anika Hüsing, Allison F. Vitonis, Theron S. Johnson, Raina N. Fichorova, Titilayo Fashemi, Hidemi S. Yamamoto, Anne Tjønneland, Louise Hansen, Kim Overvad, Marie‐Christine Boutron‐Ruault, Marina Kvaskoff, Gianluca Severi, Heiner Boeing, Antonia Trichopoulou, Eleni‐Maria Papatesta, Carlo La Vecchia, Domenico Palli, Sabina Sieri, Rosario Tumino, Carlotta Sacerdote, Amalia Mattiello, N. Charlotte Onland‐Moret, Petra H. Peeters, H. B(as) Bueno‐de‐Mesquita, Elisabete Weiderpass, J. Ramón Quirós, Eric J. Duell, Maria‐Jose Sánchez, Carmen Navarro, Eva Ardanaz, Nerea Larrañaga, Björn Nodin, Karin Jirström, Annika Idahl, Eva Lundin, Kay‐Tee Khaw, Ruth C. Travis, Marc Gunter, Mattias Johansson, Laure Dossus, Melissa A. Merritt, Elio Riboli, Kathryn L. Terry, Daniel W. Cramer, Rudolf Kaaks
Institutions: German Cancer Research Center, Brigham and Women's Hospital, Harvard University, Danish Cancer Society, Aarhus University, Université Paris-Sud, Inserm, Institut Gustave Roussy, Centre de recherche en Epidémiologie et Santé des Populations, Fondation Gustave Roussy, Italian institute for Genomic Medicine, German Institute of Human Nutrition, National and Kapodistrian University of Athens, Hellenic Health Foundation, University of Milan, Istituto per lo Studio e la Prevenzione Oncologica, Fondazione IRCCS Istituto Nazionale dei Tumori, Piedmont Reference Center for Epidemiology and Cancer Prevention, University of Turin, Federico II University Hospital, University of Naples Federico II, University Medical Center Utrecht, MRC Centre for Environment and Health, Imperial College London, National Institute for Public Health and the Environment, Karolinska Institutet, Cancer Registry of Norway, Folkhälsans Forskningscentrum, UiT The Arctic University of Norway, Gobierno del Principado de Asturias, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Universidad de Granada, Instituto de Investigación Biosanitaria de Granada, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Andalusian School of Public Health, Instituto Murciano de Investigación Biosanitaria, Instituto de Salud Pública de Navarra, Navarre Institute of Health Research, Basque Government, Lund University, Umeå University, University of Cambridge, University of Oxford, Centre international de recherche sur le cancer
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $5,030
Funders: World Health Organization, Deutsches Krebsforschungszentrum, Cancer Research UK, National Institute for Health and Care Research, European Commission, Institut National de la Santé et de la Recherche Médicale, Bundesministerium für Bildung und Forschung, Cancerfonden, Ligue Contre le Cancer, Vetenskapsrådet, NordForsk, Associazione Italiana per la Ricerca sul Cancro, Deutsche Krebshilfe, Institut Gustave-Roussy, Mutuelle Générale de l'Education Nationale, Hellenic Health Foundation, Medical Research Council, World Cancer Research Fund, Instituto de Salud Carlos III, National Cancer Institute
Awards: G1055973116, G1075502044, G1090603134, G1192877484, G1208621354, G1241080153, G1265254713, G1274701479, G1318397260, G1344656563, G1559294051, G172151099, G1767199718, G1788645866, G1907752718, G1952936224, G1993546569, G2131326840, G2149779140, G2149865848, G2216207056, G2235605558, G2257231888, G2336049343, G2372467518, G2409987178, G2539064604, G2561548287, G2572521044, G273148272, G2742323354, G2841678936, G2871896171, G29072894, G2924980845, G3010599472, G3049845011, G3077395769, G3149246560, G3170664214, G3189789075, G3216658785, G331404038, G3452641779, G3461390129, G3544161537, G3675143906, G3747421453, G375319704, G3816092139, G382879149, G3980646122, G4012977212, G4015156572, G4041385912, G4049848471, G4081633361, G4089957676, G4213141252, G423622538, G4303038735, G43956866, G4473162978, Health of vegetarians, G459595259, G4682079261, G4811780622, G4857818444, G4879533352, G4885864782, G490534113, G4913827001, G5004963360, G5047213743, G5119219000, G5375816427, G5406065712, G5456958854, G5578953934, G558017500, G5651954792, G569447510, G569908600, G5706284561, G5750710683, G5868006920, G5897142711, G5990830295, NIHR Senior Investigator Award, G6212483348, G6264211199, G6320156643, G640002926, G6442500046, G6486574503, G6570774229, G657255654, G6594529311, G6631454880, G6723261869, G6820515600, G6868151656, G6960682749, G7022277044, G7025202487, G7040807446, G7271584288, G7306252069, G7426181285, G7447125227, G7600088736, G7624991799, G7646326732, G7853538257, G7939399614, G7972317318, G8012318887, G8050896463, G8147327976, G817390530, G8279237360, G8331243404, G8374761964, G8407261631, G8508326818, G8525262851, G8542687542, G876765158, G8867963557, G8869854444, G8959392569, G8978728421
OpenAlex ID: W2768234754