Relationship of acid–base status with arterial stiffness in community-living elders: the Health ABC Study
Year: 2017
Type: article
Study design: Observational Study
Abstract: Background: Animal studies suggest that acidosis protects against arterial calcification, which contributes to arterial stiffness. The goal of this study was to investigate the associations of serum bicarbonate and pH with arterial stiffness in community-living older adults. Methods: We performed cross-sectional analyses among 1698 well-functioning participants 70-79 years of age. Bicarbonate and pH were measured by arterialized venous blood gas at the point of care. Bicarbonate was categorized into low (<23 mEq/L), normal (23-27.9) and high (≥28). Arterialized venous pH (AVpH) was categorized into tertiles: ≤7.40, >7.40-7.42 and >7.42. Arterial stiffness was evaluated by pulse wave velocity (PWV) and high ankle-brachial index (ABI; >1.3/incompressible). We used linear and logistic regression to evaluate the association of bicarbonate and AVpH with PWV and high ABI, respectively. Results: The mean age was 76 years and 15% had an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2. The mean bicarbonate was 25.2 ± 2.1 mEq/L and the mean AVpH was 7.41 ± 0.03. Compared with participants in the normal bicarbonate category, those in the low bicarbonate group had 8.8% higher PWV (P = 0.006) and 1.87 greater odds of high ABI (P = 0.04). However, the associations were not significant after adjusting for eGFR (P = 0.24 and 0.43, respectively). There was no difference in PWV or high ABI across AVpH tertiles. Results were similar in those with and without chronic kidney disease and after excluding participants on diuretics. Conclusions: We did not observe an independent association of bicarbonate or AVpH with arterial stiffness measured by high PWV or ABI in community-living older individuals. Future studies evaluating patients with a greater severity of chronic kidney disease and with more extreme alterations in acid-base status are warranted.
DOI: 10.1093/ndt/gfx292
Institutions: University of Rochester Medicine, University of Rochester, University of Pittsburgh, VA Pittsburgh Healthcare System, University of California San Diego, San Francisco VA Medical Center, University of California, San Francisco, Tufts Medical Center, University of Washington, Instituto Nacional de Cardiología, University of Utah, VA San Diego Healthcare System
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: American Heart Association, Georgia Clinical and Translational Science Alliance, National Institutes of Health, National Institute on Aging, National Institute of Nursing Research, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences
Awards: G100949702, Institutional Career Development Core, G191032694, Peripheral nerve decline: an underappreciated cause of injurious falls, G2741792843, G4390123791, G4559308260, G640327682, End of Life in the Very Old, G670738241, Role of Mitochondrial Health in Acute and Chronic Kidney Disease in Older Adults, G723808619, G7727018999, G783845518, G861947890, G88327988, Pittsburgh Older Americans Independence Center
OpenAlex ID: W2768464960