Work

MAFB enhances oncogenic Notch signaling in T cell acute lymphoblastic leukemia

Year: 2017

Type: article

Abstract: , and sustained MAFB knockdown impaired T-ALL growth in a competitive setting. MAFB bound to ETS2 and interacted with the acetyltransferases PCAF and P300, highlighting its importance in recruiting coactivators that enhance Notch1 signaling. Together, these data identify a mechanism for enhancing the oncogenic potential of weak Notch1 mutants in leukemia models, and they reveal the MAFB-ETS2 transcriptional axis as a potential therapeutic target in T-ALL.

Source: Science Signaling

DOI: 10.1126/scisignal.aam6846

Authors: Kostandin V. Pajcini, Lanwei Xu, Lijian Shao, Jelena Petrovic, Karol Palasiewicz, Yumi Ohtani, Will Bailis, Curtis Lee, Gerald B. Wertheim, Rajeswaran Mani, Natarajan Muthusamy, Yunlei Li, Jules P. P. Meijerink, Stephen C. Blacklow, Robert B. Faryabi, Sara Cherry, Warren S. Pear

Institutions: University of Illinois Chicago, Abramson Cancer Center, University of Pennsylvania, The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, Erasmus MC, Princess Máxima Center, Harvard University

Language: English

Topic: Acute Lymphoblastic Leukemia research

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, NIH Office of the Director, National Cancer Institute, National Institute of Allergy and Infectious Diseases

Awards: G1240806148, G1403651065, G1800478727, G202223731, G2336355939, G2648100544, G2711568323, G3968619285, G522626033, G6694682254, G7018074138, G9000197984, Training Program in Cardiovascular Biology and Medicine

OpenAlex ID: W2768584185

FWCI: 1.177

Cites: 54

Cited by: 20

Related to: 10