Consequences of replication fork stalling at secondary structures
Year: 2011
Type: other
Abstract: Copyright information:Taken from "Inverted repeat-stimulated sister-chromatid exchange events are -independent but reduced in a mutant"Nucleic Acids Research 2005;33(16):5243-5249.Published online 15 Sep 2005PMCID:PMC1216339.© The Author 2005. Published by Oxford University Press. All rights reserved () Pausing at the replication fork can lead to template switching. Template switching can form a wild-type gene. The large loop must be preserved from mismatch repair until the next round of DNA replication, or else be repaired in favor of loop retention, to generate a His cell. (). A DSB formed due to nicking of the secondary structure within the triplet repeat sequence may be repaired by an intra-chromosomal single-strand annealing-like event, leading to contraction of the repeat tract. The hatch marks represent the repeated units.
Source: Figshare
Authors: Nag, Dilip K., Fasullo, Michael, Dong, Zheng, Tronnes, Ashlie
Language: English
Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6958727811