Work

The mouse viral outgrowth assay: avatars for the detection of HIV-1 reservoirs

Year: 2017

Type: article

Abstract: Sensitive assays are needed for the detection of residual viral reservoirs in HIV-1-infected subjects on suppressive combination antiretroviral therapy regimens to determine whether eradication strategies are effective. Mouse viral outgrowth assays have recently been developed and have the potential to be more sensitive than traditional in vitro quantitative viral outgrowth assays. In this article we describe these assays and review several studies that have used them to measure the latent reservoir.

Source: Retrovirology

DOI: 10.1186/s12977-017-0376-z

Authors: Kelly A. Metcalf Pate, Joel N. Blankson

Institutions: Johns Hopkins University, Johns Hopkins Medicine, Johns Hopkins University Center for AIDS Research

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,890