Work

Development and differentiation of early innate lymphoid progenitors

Year: 2017

Type: article

Abstract: Early innate lymphoid progenitors (EILPs) have recently been identified in mouse adult bone marrow as a multipotential progenitor population specified toward innate lymphoid cell (ILC) lineages, but their relationship with other described ILC progenitors is still unclear. In this study, we examine the progenitor-successor relationships between EILPs, all-lymphoid progenitors (ALPs), and ILC precursors (ILCps). Functional, bioinformatic, phenotypical, and genetic approaches collectively establish EILPs as an intermediate progenitor between ALPs and ILCps. Our work additionally provides new candidate regulators of ILC development and clearly defines the stage of requirement of transcription factors key for early ILC development.

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.20170832

Authors: Christelle Harly, Maggie Cam, Jonathan Kaye, Avinash Bhandoola

Institutions: National Institutes of Health, National Cancer Institute, Center for Cancer Research, Cedars-Sinai Medical Center

Language: English

Topic: IL-33, ST2, and ILC Pathways

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Cancer Institute, National Institute of Allergy and Infectious Diseases