Work

The Diabetic Dog as a Translational Model for Human Islet Transplantation.

Year: 2017

Type: article

Abstract: The dog model has served as the primary method for early development of many diabetes therapies, including pancreatic islet transplantation techniques and immunosuppressive protocols. Recent trends towards the use of monoclonal antibody therapies for immunosuppression in human islet transplantation have led to the increasing use of primate models with induced diabetes. In addition to induced-disease models in large animals, scientists in many fields are considering the use of naturally-occurring disease models in client-owned pets. This article will review the applicability of naturally-occurring diabetes in dogs as a translational model for developing islet transplantation in the human diabetic patient.

Source: Europe PMC (PubMed Central)

Authors: Christopher A Adin, Chen Gilor

Institutions: North Carolina State University, University of California, Davis

Language: English

Topic: Pancreatic function and diabetes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2769330882

FWCI: 3.08

Cites: 69

Cited by: 23

Related to: 10