Ultrasound-Induced Microbubble Cavitation for the Treatment of Catheterization-Induced Vasospasm
Year: 2017
Type: article
Abstract: Inertial cavitation inducing ultrasound-mediated microbubble treatments can produce resolution of vasospasm and restoration of distal arterial flow after peripheral artery injury. Resolution of catheter-induced vasospasm is likely to be nitric oxide- mediated because improvements in stenosis diameter and downstream blood flow were blunted following pretreatment with L-NAME. The potential for clinical applicability of this therapy is significant because: 1) microbubbles can be delivered systemically into the site of injury enabling relatively high local concentration; 2) targeted transcutaneous ultrasound delivery is achievable due to the proximity of vessels; and 3) microbubbles and diagnostic ultrasound system used are commercially available.
Institutions: Creighton University, Children's Hospital & Medical Center, University of Nebraska Medical Center, Central South University, Second Xiangya Hospital of Central South University, Xiangya Hospital Central South University, First Affiliated Hospital of University of South China, Nebraska Medical Center
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $4,750
OpenAlex ID: W2769372673