Year: 2017
Type: editorial
Abstract: The complex nature of an organ, made up of multiple tissue and cells types, poses an incredible challenge to biologists wishing to interrogate homeostasis or disease. Because of this complexity, it often is difficult to ascertain the cause-and-effect relationship of an experimental manipulation in these systems. For example, in the intestine, a perturbation to the epithelium may elicit an immune response; however, it is difficult to determine if this response is a direct result of the epithelial perturbation, or a consequence of a secondary effect, such as translocation of bacteria across the epithelium.
Author: Jason R. Spence
Institutions: University of Michigan, Michigan Medicine
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,430
Awards: Limited Competition for the Continuation of the Intestinal Stem Cell Consortium Coordinating Center, Engineered human intestinal organoids: a modular system to model enteric disease, G827612554, Intestinal Stem Cell Consortium Coordinating Center, Niche support of human intestinal stem cells
OpenAlex ID: W2769542972